Systematic Review of Adherence and Persistence Rates With Long-Acting Injectable Dopamine Receptor Blocking Agents
This is a systematic review and meta-analysis of 34 studies where dopamine receptor blocking agents (DRBAs) were used to treat patients with psychiatric diagnoses. The investigators examine the efficacy of long-acting injectable dopamine receptor blocking agents (LAIDRBA) across multiple cohorts with different rates of adherence and continuity of treatment. The article dives into the various barriers that impact the use of these injectables (vs oral treatments) such as age, gender, ethnicity, homelessness, and involuntary inpatient admission. These barriers were separated into three categories of patient-related, medication-related, and service-related factors.
Reference: Lee S, Schwartz S. Adherence and persistence to long-acting injectable dopamine receptor blocking agent therapy in the United States: A systematic review and meta-analysis of cohort studies. Psychiatry Res. 2021;306:114277. doi:10.1016/j.psychres.2021.114277