In a narrative review, researchers examine the present research and notable progress over the past 5 years of the genetic and epigenetic elements that are part of antipsychotic response. The researchers hone in on commonly prescribed antipsychotics as well as consistent pharmacogenetic evidence on pharmacokinetic genes and pharmacodynamic genes concerning dopamine, serotonin, and glutamate neurotransmission. Antipsychotic response with a focus on the measurement of DNA methylation is also reviewed. The researchers also consider genetic and epigenetic aspects that play a part in antipsychotic response as well as adverse effects that they note will be notable in personalized medicine. Through their review, the researchers offer recommendations for future research and clinical evaluation.

Reference: Lisoway AJ, Chen CC, Zai CC, Tiwari AK, Kennedy JL. Toward personalized medicine in schizophrenia: Genetics and epigenetics of antipsychotic treatment. Schizophr Res. 2021;232:112-124. doi:10.1016/j.schres.2021.05.010