Schizophrenia continues to challenge researchers due to its complex nature and a lack of coherent understanding, despite extensive studies. Recent efforts to consolidate knowledge about schizophrenia include a multi-phase project by 50 international experts, leading to a comprehensive review. Researchers emphasize genetic variations, network dysconnectivity, and the effectiveness of early interventions. Despite the growth in data, links between different aspects of the disease remain underdeveloped, highlighting the need for a reevaluation of the schizophrenia construct.

The researchers of the study suggests that the current categorical concept of schizophrenia is inadequate, indicating the necessity for a broader, multi-dimensional approach to better fit known facts and guide future research and treatment strategies.

Reference: Tandon R, Nasrallah H, Akbarian S, et al. The schizophrenia syndrome, circa 2024: What we know and how that informs its nature. Schizophr Res. Published online December 11, 2023. doi:10.1016/j.schres.2023.11.015