Researchers explored the clinical aspects and causes of cognitive deficits, a core aspect of schizophrenia, examining the roles of dopamine, cholinergic signaling, and neuronal balance. While treating cognitive impairments in schizophrenia is challenging due to complex neurobiology, emerging clinical interventions and novel treatments show potential. The development of effective therapies for these cognitive deficits could mark a significant breakthrough in schizophrenia treatment, akin to the advent of D2 antagonists.

Reference: McCutcheon RA, Keefe RSE, McGuire PK. Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment. Mol Psychiatry. 2023 May;28(5):1902-1918. doi: 10.1038/s41380-023-01949-9. Epub 2023 Jan 23. Erratum in: Mol Psychiatry. 2023 Feb 2;: PMID: 36690793; PMCID: PMC10575791.