A study analyzed how schizophrenia’s polygenic risk and exposome scores impact health, noting age and sex differences. Analyzing data from 3099 and 6264 participants, it found that age influences the link between exposome scores and health deterioration, particularly in older individuals. Furthermore, exposome scores more negatively affect physical health in females. These results indicate that higher exposome scores are associated with worse health outcomes, especially among older and female groups, emphasizing their consideration in schizophrenia studies.

Reference: Paquin V, Pries LK, Ten Have M, et al. Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population. Soc Psychiatry Psychiatr Epidemiol. 2023 Jan;58(1):43-52. doi: 10.1007/s00127-022-02346-3. Epub 2022 Aug 1. PMID: 35913550; PMCID: PMC9845157.